ABSTRACT
Objective: To investigate the clinical and laboratory characteristics of endocrine diseases complicated with rhabdomyolysis (RM). Methods: We made a retrospective analysis of clinical features, diagnosis and treatment of 10 cases of endocrine diseases induced RM among 144 RM patients admitted to The First Affiliated Hospital of Xi'an Jiaotong University from June 2008 to May 2019. Results: Primary hypothyroidism was the most common endocrine etiology leading to RM. Other etiologies included diabetic ketosis, hyperglycemic hyperosmolar syndrome, diabetic nephropathy, hyperaldosteronism and Cushing syndrome. The onset of RM caused by endocrine diseases was insidious, lacking the typical triad of myalgia, muscle weakness and colored urine. Complications such as acute kidney injury and multiple-organ dysfunction syndrome were less common in RM caused by endocrine diseases. These patients seldom needed continuous renal replacement therapy, and good prognosis could be attained via routine fluid infusion and alkalization treatment. Conclusion: Many endocrine diseases can cause RM and their clinical manifestations are often atypical. Clinicians should be vigilant for early identification. Treatment should be comprehensive to improve the prognosis.